Modulation of autophagy in exJSRV-env-transfected cells through the Akt/mTOR and MAPK signaling pathway.
Identifieur interne : 000796 ( Main/Exploration ); précédent : 000795; suivant : 000797Modulation of autophagy in exJSRV-env-transfected cells through the Akt/mTOR and MAPK signaling pathway.
Auteurs : Xiaolin Sun [République populaire de Chine] ; Fangyuan Du [République populaire de Chine] ; Shuying Liu [République populaire de Chine]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2017.
Descripteurs français
- KwdFr :
- Adénomatose pulmonaire ovine (génétique), Adénomatose pulmonaire ovine (métabolisme), Adénomatose pulmonaire ovine (virologie), Animaux (MeSH), Autophagie (MeSH), Cellules NIH 3T3 (MeSH), Extracellular Signal-Regulated MAP Kinases (métabolisme), Fibroblastes (métabolisme), Fibroblastes (virologie), Immunohistochimie (MeSH), Immunotransfert (MeSH), Interactions hôte-pathogène (MeSH), JNK Mitogen-Activated Protein Kinases (métabolisme), Ovis (MeSH), Phosphorylation (MeSH), Poumon (métabolisme), Poumon (virologie), Produits du gène env (génétique), Produits du gène env (métabolisme), Protéines proto-oncogènes c-akt (métabolisme), Rétrovirus Jaagsiekte du mouton (génétique), Rétrovirus Jaagsiekte du mouton (métabolisme), Rétrovirus Jaagsiekte du mouton (physiologie), Souris (MeSH), Système de signalisation des MAP kinases (MeSH), Sérine-thréonine kinases TOR (métabolisme), p38 Mitogen-Activated Protein Kinases (métabolisme).
- MESH :
- génétique : Adénomatose pulmonaire ovine, Produits du gène env, Rétrovirus Jaagsiekte du mouton.
- métabolisme : Adénomatose pulmonaire ovine, Extracellular Signal-Regulated MAP Kinases, Fibroblastes, JNK Mitogen-Activated Protein Kinases, Poumon, Produits du gène env, Protéines proto-oncogènes c-akt, Rétrovirus Jaagsiekte du mouton, Sérine-thréonine kinases TOR, p38 Mitogen-Activated Protein Kinases.
- physiologie : Rétrovirus Jaagsiekte du mouton.
- virologie : Adénomatose pulmonaire ovine, Fibroblastes, Poumon.
- Animaux, Autophagie, Cellules NIH 3T3, Immunohistochimie, Immunotransfert, Interactions hôte-pathogène, Ovis, Phosphorylation, Souris, Système de signalisation des MAP kinases.
English descriptors
- KwdEn :
- Animals (MeSH), Autophagy (MeSH), Extracellular Signal-Regulated MAP Kinases (metabolism), Fibroblasts (metabolism), Fibroblasts (virology), Gene Products, env (genetics), Gene Products, env (metabolism), Host-Pathogen Interactions (MeSH), Immunoblotting (MeSH), Immunohistochemistry (MeSH), JNK Mitogen-Activated Protein Kinases (metabolism), Jaagsiekte sheep retrovirus (genetics), Jaagsiekte sheep retrovirus (metabolism), Jaagsiekte sheep retrovirus (physiology), Lung (metabolism), Lung (virology), MAP Kinase Signaling System (MeSH), Mice (MeSH), NIH 3T3 Cells (MeSH), Phosphorylation (MeSH), Proto-Oncogene Proteins c-akt (metabolism), Pulmonary Adenomatosis, Ovine (genetics), Pulmonary Adenomatosis, Ovine (metabolism), Pulmonary Adenomatosis, Ovine (virology), Sheep (MeSH), TOR Serine-Threonine Kinases (metabolism), p38 Mitogen-Activated Protein Kinases (metabolism).
- MESH :
- chemical , genetics : Gene Products, env.
- chemical , metabolism : Extracellular Signal-Regulated MAP Kinases, Gene Products, env, JNK Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, p38 Mitogen-Activated Protein Kinases.
- genetics : Jaagsiekte sheep retrovirus, Pulmonary Adenomatosis, Ovine.
- metabolism : Fibroblasts, Jaagsiekte sheep retrovirus, Lung, Pulmonary Adenomatosis, Ovine.
- physiology : Jaagsiekte sheep retrovirus.
- virology : Fibroblasts, Lung, Pulmonary Adenomatosis, Ovine.
- Animals, Autophagy, Host-Pathogen Interactions, Immunoblotting, Immunohistochemistry, MAP Kinase Signaling System, Mice, NIH 3T3 Cells, Phosphorylation, Sheep.
Abstract
The envelope (Env) of Jaagsiekte sheep retrovirus (JSRV) is an oncoprotein of ovine pulmonary adenocarcinoma (OPA). Autophagy is involved in different cancers, but how it is carcinogenic in JSRV Env is unclear. Modulation of autophagy in exJSRV-env-NM-transfected cells through the Akt/mTOR and MAPK signaling pathway was studied, and we observed strong positive labeling of p-Akt, p-mTOR, p-MEK1/2, p-ERK1/2, p-p38 and p-JNK in tumor cells and typical type II pneumocytes in naturally infected OPA lung tissues, which was co-aligned with JSRV-Env positive cells as shown by immunohistochemical and microscopic analysis. Akt/mTOR and MAPK pathways were activated in OPA lung and JSRV-Env transfected NIH 3T3 cells. Decreased Beclin1 and LC3 II/I suggested that autophagy was inhibited in OPA lung and JSRV-Env transfected NIH 3T3 cells. Beclin1 and LC3 II/I increased in JSRV-Env transfected NIH3T3 cells treated with mTOR inhibitor (rapamycin), ERK1/2 inhibitor (PD 98059), p38 inhibitor (SB 203580) and JNK inhibitor (SP 600125), suggesting that Akt/mTOR and MAPK pathways were responsible for JSRV-Env decreased autophagy. In conclusion, JSRV Env decreased autophagy in JSRV-Env transfected NIH3T3 cells through Akt/mTOR and MAPK pathways, in particular, JNK and p38 pathways.
DOI: 10.1016/j.bbrc.2017.02.099
PubMed: 28235485
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(metabolism)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Immunoblotting (MeSH)</term><term>Immunohistochemistry (MeSH)</term><term>JNK Mitogen-Activated Protein Kinases (metabolism)</term><term>Jaagsiekte sheep retrovirus (genetics)</term><term>Jaagsiekte sheep retrovirus (metabolism)</term><term>Jaagsiekte sheep retrovirus (physiology)</term><term>Lung (metabolism)</term><term>Lung (virology)</term><term>MAP Kinase Signaling System (MeSH)</term><term>Mice (MeSH)</term><term>NIH 3T3 Cells (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Proto-Oncogene Proteins c-akt (metabolism)</term><term>Pulmonary Adenomatosis, Ovine (genetics)</term><term>Pulmonary Adenomatosis, Ovine (metabolism)</term><term>Pulmonary Adenomatosis, Ovine (virology)</term><term>Sheep (MeSH)</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>p38 Mitogen-Activated Protein Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adénomatose pulmonaire ovine (génétique)</term><term>Adénomatose pulmonaire ovine (métabolisme)</term><term>Adénomatose pulmonaire ovine (virologie)</term><term>Animaux (MeSH)</term><term>Autophagie (MeSH)</term><term>Cellules NIH 3T3 (MeSH)</term><term>Extracellular Signal-Regulated MAP Kinases (métabolisme)</term><term>Fibroblastes (métabolisme)</term><term>Fibroblastes (virologie)</term><term>Immunohistochimie (MeSH)</term><term>Immunotransfert (MeSH)</term><term>Interactions hôte-pathogène (MeSH)</term><term>JNK Mitogen-Activated Protein Kinases (métabolisme)</term><term>Ovis (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Poumon (métabolisme)</term><term>Poumon (virologie)</term><term>Produits du gène env (génétique)</term><term>Produits du gène env (métabolisme)</term><term>Protéines proto-oncogènes c-akt (métabolisme)</term><term>Rétrovirus Jaagsiekte du mouton (génétique)</term><term>Rétrovirus Jaagsiekte du mouton (métabolisme)</term><term>Rétrovirus Jaagsiekte du mouton (physiologie)</term><term>Souris (MeSH)</term><term>Système de signalisation des MAP kinases (MeSH)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>p38 Mitogen-Activated Protein Kinases (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Gene Products, env</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Extracellular Signal-Regulated MAP Kinases</term><term>Gene Products, env</term><term>JNK Mitogen-Activated Protein Kinases</term><term>Proto-Oncogene Proteins c-akt</term><term>TOR Serine-Threonine Kinases</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Jaagsiekte sheep retrovirus</term><term>Pulmonary Adenomatosis, Ovine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénomatose pulmonaire ovine</term><term>Produits du gène env</term><term>Rétrovirus Jaagsiekte du mouton</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fibroblasts</term><term>Jaagsiekte sheep retrovirus</term><term>Lung</term><term>Pulmonary Adenomatosis, Ovine</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénomatose pulmonaire ovine</term><term>Extracellular Signal-Regulated MAP Kinases</term><term>Fibroblastes</term><term>JNK Mitogen-Activated Protein Kinases</term><term>Poumon</term><term>Produits du gène env</term><term>Protéines proto-oncogènes c-akt</term><term>Rétrovirus Jaagsiekte du mouton</term><term>Sérine-thréonine kinases TOR</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Rétrovirus Jaagsiekte du mouton</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Jaagsiekte sheep retrovirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Adénomatose pulmonaire ovine</term><term>Fibroblastes</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Fibroblasts</term><term>Lung</term><term>Pulmonary Adenomatosis, Ovine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Autophagy</term><term>Host-Pathogen Interactions</term><term>Immunoblotting</term><term>Immunohistochemistry</term><term>MAP Kinase Signaling System</term><term>Mice</term><term>NIH 3T3 Cells</term><term>Phosphorylation</term><term>Sheep</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Cellules NIH 3T3</term><term>Immunohistochimie</term><term>Immunotransfert</term><term>Interactions hôte-pathogène</term><term>Ovis</term><term>Phosphorylation</term><term>Souris</term><term>Système de signalisation des MAP kinases</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The envelope (Env) of Jaagsiekte sheep retrovirus (JSRV) is an oncoprotein of ovine pulmonary adenocarcinoma (OPA). Autophagy is involved in different cancers, but how it is carcinogenic in JSRV Env is unclear. Modulation of autophagy in exJSRV-env-NM-transfected cells through the Akt/mTOR and MAPK signaling pathway was studied, and we observed strong positive labeling of p-Akt, p-mTOR, p-MEK1/2, p-ERK1/2, p-p38 and p-JNK in tumor cells and typical type II pneumocytes in naturally infected OPA lung tissues, which was co-aligned with JSRV-Env positive cells as shown by immunohistochemical and microscopic analysis. Akt/mTOR and MAPK pathways were activated in OPA lung and JSRV-Env transfected NIH 3T3 cells. Decreased Beclin1 and LC3 II/I suggested that autophagy was inhibited in OPA lung and JSRV-Env transfected NIH 3T3 cells. Beclin1 and LC3 II/I increased in JSRV-Env transfected NIH3T3 cells treated with mTOR inhibitor (rapamycin), ERK1/2 inhibitor (PD 98059), p38 inhibitor (SB 203580) and JNK inhibitor (SP 600125), suggesting that Akt/mTOR and MAPK pathways were responsible for JSRV-Env decreased autophagy. In conclusion, JSRV Env decreased autophagy in JSRV-Env transfected NIH3T3 cells through Akt/mTOR and MAPK pathways, in particular, JNK and p38 pathways.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28235485</PMID><DateCompleted><Year>2017</Year><Month>06</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>485</Volume><Issue>3</Issue><PubDate><Year>2017</Year><Month>Apr</Month><Day>08</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>Modulation of autophagy in exJSRV-env-transfected cells through the Akt/mTOR and MAPK signaling pathway.</ArticleTitle><Pagination><MedlinePgn>672-678</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(17)30388-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2017.02.099</ELocationID><Abstract><AbstractText>The envelope (Env) of Jaagsiekte sheep retrovirus (JSRV) is an oncoprotein of ovine pulmonary adenocarcinoma (OPA). Autophagy is involved in different cancers, but how it is carcinogenic in JSRV Env is unclear. Modulation of autophagy in exJSRV-env-NM-transfected cells through the Akt/mTOR and MAPK signaling pathway was studied, and we observed strong positive labeling of p-Akt, p-mTOR, p-MEK1/2, p-ERK1/2, p-p38 and p-JNK in tumor cells and typical type II pneumocytes in naturally infected OPA lung tissues, which was co-aligned with JSRV-Env positive cells as shown by immunohistochemical and microscopic analysis. Akt/mTOR and MAPK pathways were activated in OPA lung and JSRV-Env transfected NIH 3T3 cells. Decreased Beclin1 and LC3 II/I suggested that autophagy was inhibited in OPA lung and JSRV-Env transfected NIH 3T3 cells. Beclin1 and LC3 II/I increased in JSRV-Env transfected NIH3T3 cells treated with mTOR inhibitor (rapamycin), ERK1/2 inhibitor (PD 98059), p38 inhibitor (SB 203580) and JNK inhibitor (SP 600125), suggesting that Akt/mTOR and MAPK pathways were responsible for JSRV-Env decreased autophagy. In conclusion, JSRV Env decreased autophagy in JSRV-Env transfected NIH3T3 cells through Akt/mTOR and MAPK pathways, in particular, JNK and p38 pathways.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Xiaolin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot 010018, China. Electronic address: yolo_1010@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Fangyuan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot 010018, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Shuying</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot 010018, China. Electronic address: liushuying@hotmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015686">Gene Products, env</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D048049">Extracellular Signal-Regulated MAP Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D048031">JNK Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D048051">p38 Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="Y">Autophagy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048049" MajorTopicYN="N">Extracellular Signal-Regulated MAP Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015686" MajorTopicYN="N">Gene Products, env</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015151" MajorTopicYN="N">Immunoblotting</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048031" MajorTopicYN="N">JNK Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D022141" MajorTopicYN="N">Jaagsiekte sheep retrovirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020935" MajorTopicYN="Y">MAP Kinase Signaling System</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D041681" MajorTopicYN="N">NIH 3T3 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011648" MajorTopicYN="N">Pulmonary Adenomatosis, Ovine</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048051" MajorTopicYN="N">p38 Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Envelope</Keyword><Keyword MajorTopicYN="N">Jaagsiekte sheep retrovirus</Keyword><Keyword MajorTopicYN="N">Ovine pulmonary adenocarcinoma</Keyword><Keyword MajorTopicYN="N">Signaling pathway</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28235485</ArticleId><ArticleId IdType="pii">S0006-291X(17)30388-1</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2017.02.099</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Sun, Xiaolin" sort="Sun, Xiaolin" uniqKey="Sun X" first="Xiaolin" last="Sun">Xiaolin Sun</name></noRegion><name sortKey="Du, Fangyuan" sort="Du, Fangyuan" uniqKey="Du F" first="Fangyuan" last="Du">Fangyuan Du</name><name sortKey="Liu, Shuying" sort="Liu, Shuying" uniqKey="Liu S" first="Shuying" last="Liu">Shuying Liu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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